In the Starter and Advanced ranges, once the DNA is extracted from the saliva sample, an amplification process is performed (many copies of it are generated) in order to carry out the genotyping process effectively. This process consists of identifying a specific number of positions in the DNA sequence to detect possible variants present in said genetic material. This detection is performed by comparing the sample with a genotyping chip or reference DNA, which has been validated and approved by the scientific community.
During our first years of activity, for the analysis of samples, we exclusively used information derived from a customized version of the illuminaTM Global Screening Array v3.0 genotyping array, which is capable of analyzing around 650,000 genome positions. This was also customized by including more than 100,000 additional positions that had been previously selected to obtain additional relevant clinical information.
Now, at tellmeGen we apply a combination of genetic knowledge and computational power to significantly increase the number of analyzable variants with a DNA chip up to tens of millions. This imputation analysis allows us to study variants that have been associated with diseases and that were not present in the initial 750,000+ variants. With this, we achieve our goal: estimating each individual's genetic risk more accurately than ever.
This important update allows us to significantly improve our process of predictive genetics, which, as its name suggests, allows us to predict from a genetic point of view the probability of developing diseases or possessing complex traits.
It is important to note that the genetic analysis is performed in certified laboratories that have all the corresponding regulations to offer the highest quality standards, guaranteeing the accuracy and reliability of the results.
Array Scanner: illumina® iScan
Genotyping chip: illuminaTM Global Screening Array – Customize version
Laboratory: Our reference laboratory is Eurofins Genomics Denmark, the only laboratory in Europe capable of processing the high number of samples we receive and process daily.
It is a reference laboratory in Europe with the following certifications:
ISO 17025: Accredited analytical excellence ISO 13485: Oligonucleotides according to the medical device standard GLP: The gold standard for conducting non-clinical safety studies GCP: Pharmacogenomics services for clinical studies cGMP: Products and testing according to pharmaceutical and biotechnology requirements