It is important that you are aware of the limitations of this technology:
- It is not a diagnostic test. The results are informative, preventive, and for wellness. You should not make clinical decisions without first consulting a qualified healthcare professional. A genetic predisposition does not equate to a diagnosis.
- Variable coverage. Although the average coverage is 30x, there are regions of the genome that are difficult to sequence (highly repetitive areas, telomeres, centromeres) where reliability may be lower.
- Detection of structural variants. They are detected with high reliability, but some very small variants or those located in complex regions may not be identified. Certain long genetic expansions may require specific confirmatory testing.
- Mosaicism. Low-level genetic mosaicisms (the presence of different cell populations in an individual) may not be detected.
- Mitochondrial DNA. We do not currently analyze very low-level heteroplasmies (mitochondrial variants).
- Ancestry. The accuracy of the results depends on the representation of your population of origin in the reference databases.
- Pharmacogenetics. This report is not available in the USA. Where it is available, recommendations must always be interpreted by a professional.