- It is not a diagnostic test. Results are for information only. Genetic susceptibility is not a diagnosis, and no clinical decision should be made without a healthcare professional.
- Variable coverage. The 30× coverage is an average: some highly repetitive or complex regions of the genome are harder to read.
- Variants that are difficult to detect. Copy number variants, complex rearrangements, repeat expansions and variants in genes with sequences very similar to others, such as genes with pseudogenes, are difficult to detect reliably. Structural variants and repeat expansions are not currently interpreted in the reports, and results for genes with pseudogenes may be less accurate.
- Mosaicism and somatic variants. The analysis is designed for germline variants, present in all your cells; low-level mosaicism may not be detected.
- Variants of uncertain significance. These are not included in the standard report; you can request them in a separate paid report.
- Ancestry. Accuracy depends on how well your population is represented in the reference databases.
- Pharmacogenetics. The test does not analyse every variant that affects the response to a medicine. In the United States, this information is only available after a prior medical review, and in all countries it must be assessed by a healthcare professional.