Reliability depends on two things: reading the DNA and interpreting it.
- Reading the DNA. Genotyping is more than 99% accurate for common variants; imputed variants are slightly less accurate, which is why we only use those that pass our quality checks. With Ultra, each position in the genome is read an average of about 30 times, allowing rare variants to be detected too.
- Interpretation. Our geneticists only include associations published in peer-reviewed scientific journals, based on large studies with statistically significant results. The technical report for each result shows the variants analysed and the references.
Please bear in mind an important limitation: genotyping chips are not reliable for very rare variants, such as many of those associated with hereditary conditions. Any relevant finding must therefore be confirmed with a diagnostic test in a clinical laboratory before any decisions are made.